Please note: This review reflects information we gathered on the date it was researched and may now be out of date. Providers frequently change their pricing, plans, medications, and policies. Any ratings, reviews, and customer feedback are gathered from publicly available online sources and may have since changed or no longer be accurate. Always do your own research and confirm the latest details directly with the provider before making any decision.
Enhance MD Review
An in-depth look at Enhance.MD — a physician-led weight management platform that bundles mandatory lab work into a flat monthly price. The labs are a genuine clinical advantage. The price is at the top of the market, and eleven states are excluded.
Enhance MD
Labs IncludedEnhance.MD is a telehealth weight-management platform offering compounded semaglutide and tirzepatide alongside an NAD+ program, founded in 2019 — making it one of the older operators in a category full of brands launched last year. Care runs through licensed providers who assess eligibility, prescribe, and review progress at follow-ups every 90 days or sooner.
The thing that genuinely distinguishes it is that comprehensive metabolic lab work through Quest Diagnostics is both mandatory and included in the price. Most cash-pay GLP-1 platforms either skip labs entirely or bill them separately at $100–$300. Requiring bloodwork before and during treatment is the clinically correct approach, and building it into one fee removes the incentive to skip it.
It also has a clean regulatory record. We searched the FDA warning letter database and found nothing against Enhance.MD — worth stating because a dozen providers reviewed on this site do have letters. Reported third-party feedback is strong, with an A+ BBB rating and a Trustpilot average near 4.9 across roughly 3,000 reviews, though we could not verify those figures directly.
What holds the rating at 4.2 is cost and coverage. At $249/month for semaglutide and $379/month for tirzepatide month-to-month, this is near the top of the market — you are paying a real premium for the included labs. And the offer is unavailable in eleven states, which is a wide exclusion. Compounded medications are also not FDA-approved, and now that neither drug is in shortage, ask what clinical basis supports compounding in your case.
Affiliate disclosure: GLP1Drugs.org earns a commission if you sign up through the links on this page. It does not affect our rating. Pricing was checked on 29 July 2026 and reflects third-party reporting where the company does not publish a full rate card.
Visit Enhance MDOur Top Recommended Provider: CoreAge Rx
After reviewing dozens of GLP-1 telehealth providers, CoreAge Rx is the one we recommend most. CoreAge Rx is one of our partners — read on for why we recommend them:
Flat-Rate Pricing
Same cost at every dose level — no price jumps as you titrate up.
Verified Pharmacies
US-licensed physicians and NABP-verified 503A compounding pharmacies you can trust.
Everything Included
Medication, supplies, free shipping, and ongoing clinical support — no hidden fees.
Active Community of Members
Ask questions, share progress, and get answers from other patients on the same journey — alongside ongoing clinical support from your care team.
$249
Semaglutide / Month
$379
Tirzepatide / Month
Included
Quest Lab Work
11
States Excluded
Plans & Pricing
Reported pricing as of 29 July 2026. Annual commitment lowers the effective monthly rate substantially.
| Plan | First Month | Month-to-Month | On Annual Plan | Labs Included |
|---|---|---|---|---|
| Semaglutide (Core) | $49 | $249/mo | ~$212/mo | Yes |
| Tirzepatide (Advanced) | — | $379/mo | ~$322/mo | Yes |
| NAD+ injectable | — | $199/mo | $169/mo | Yes |
The $49 first month on the Core plan is a genuine trial price, and it is the sensible way in — it lets you find out whether you tolerate the medication before committing to $249/month. Note the gap between month-to-month and annual is roughly $37–$57 a month, so the annual plan only pays off if you are confident you will stay on treatment for a year.
What's Included
Compounded Semaglutide
The active ingredient in Ozempic and Wegovy, compounded by licensed US pharmacies — not FDA-approved and not the branded product
Compounded Tirzepatide
The dual GIP/GLP-1 agonist found in Mounjaro and Zepbound, offered on the Advanced tier
Mandatory Lab Work
Comprehensive metabolic panels through Quest Diagnostics, included in the monthly price rather than billed separately
Provider Visits
Ongoing virtual visits with licensed providers, with follow-ups required every 90 days or sooner to continue refills
NAD+ Program
An injectable NAD+ option at $169–$199/month — marketed for longevity, an area where the evidence is far thinner than for GLP-1s
Member Portal
A secure portal for lab results, provider messaging and treatment management
Pros & Cons
Pros
- ✓Mandatory lab work included in the price — the clinically correct approach, and unusual in cash-pay GLP-1 telehealth
- ✓No FDA warning letter, unlike a dozen providers reviewed on this site
- ✓Founded 2019, so it has a longer operating history than most compounded GLP-1 platforms
- ✓$49 first month on the semaglutide plan lets you test tolerance cheaply
- ✓Both semaglutide and tirzepatide available from one provider
- ✓Reported A+ BBB rating and a Trustpilot average near 4.9 across roughly 3,000 reviews
- ✓Required 90-day follow-ups mean ongoing monitoring rather than a prescription mill
Cons
- ✕Not available in Alabama, Arkansas, Georgia, Hawaii, Louisiana, Mississippi, Missouri, North Dakota, South Carolina, Tennessee or West Virginia
- ✕Premium pricing — $249/month for semaglutide and $379/month for tirzepatide is at the top of the market
- ✕The lowest effective rates require a 12-month commitment
- ✕Compounded medications are not FDA-approved and are not evaluated by the FDA for safety, effectiveness or quality
- ✕The NAD+ offering is marketed for longevity, a claim with far weaker evidence than the GLP-1 line
- ✕Trustpilot and BBB figures come from third-party summaries we could not verify directly
- ✕No insurance accepted
Our Verdict
4.2 / 5 — the rare cash-pay GLP-1 provider that requires and includes proper lab work, with a clean FDA record; marked down for top-of-market pricing and an eleven-state exclusion.
If you are going to buy compounded GLP-1s from a telehealth platform, the ones that insist on bloodwork are the ones to prefer, and Enhance.MD both insists on it and pays for it. Combined with a 2019 founding date, required 90-day follow-ups and no FDA warning letter, that adds up to a more clinically serious operation than most of this category. You pay for it: $249 and $379 a month are premium rates, and the annual plans that soften them require real commitment. Check your state first, take the $49 first month to test tolerance, and ask what clinical basis supports compounding in your case.
Visit Enhance MDFrequently Asked Questions
How much does Enhance.MD cost?
Reported pricing as of 29 July 2026: compounded semaglutide on the Core plan is $49 for the first month and $249/month thereafter, dropping to roughly $212/month on an annual commitment. Compounded tirzepatide on the Advanced plan is $379/month, or about $322/month if you pay for a year upfront ($3,866). Injectable NAD+ runs $169–$199/month depending on plan length. Crucially, the fee covers medication, shipping, provider consults and lab work — so compare it against competitors' prices plus $100–$300 for labs, not against their headline figure alone.
Why does the lab work matter?
Because most cash-pay GLP-1 platforms do not require it, and that is a real gap. Baseline and follow-up bloodwork lets a clinician check kidney and liver function, HbA1c, lipids and thyroid markers before and during treatment — which matters when you are on a drug that changes metabolism and appetite substantially. Enhance.MD makes it mandatory through Quest and includes it in the price, which removes the financial incentive to skip it. That is the single strongest argument for paying its premium.
Which states is Enhance.MD not available in?
This offer is not available in Alabama, Arkansas, Georgia, Hawaii, Louisiana, Mississippi, Missouri, North Dakota, South Carolina, Tennessee or West Virginia. That is eleven states — a wider exclusion than most GLP-1 telehealth providers, so check your own state before starting an intake.
Is Enhance.MD legitimate?
The signals are good. It has operated since 2019, uses licensed providers, requires labs and 90-day follow-ups rather than dispensing on a questionnaire, and — importantly — we found no FDA warning letter against it. That last point carries weight in this category: the FDA has written to dozens of telehealth firms over compounded GLP-1 marketing, and several providers reviewed on this site received letters. Reported customer sentiment is strong, though those figures come from third-party summaries rather than our own verification.
Can I still get compounded GLP-1s?
It is more restricted than it was. Tirzepatide left the FDA shortage list in December 2024 and semaglutide in February 2025, and once a drug is no longer in shortage, pharmacies may not routinely compound what amounts to a copy of the commercial product. Patient-specific compounding for a documented clinical need remains lawful, and in April 2026 the FDA proposed excluding semaglutide and tirzepatide from the 503B bulk substances list. Ask Enhance.MD directly what clinical basis supports compounding for you.
What are the side effects?
Most commonly gastrointestinal — nausea, vomiting, diarrhoea and constipation — usually worst while the dose is being increased. More serious risks associated with GLP-1 receptor agonists include pancreatitis and gallbladder disease, and in animal studies thyroid C-cell tumours; these medications are contraindicated if you or a family member has had medullary thyroid carcinoma or MEN 2. They should not be used in pregnancy. Discuss your own history with the prescribing clinician.
Ready to Get Started?
Check your state is served first — eleven are excluded — and confirm whether your quoted price is the monthly or the annual-commitment rate.
Visit Enhance MDCompare Other GLP-1 Providers
See how other telehealth providers stack up.
CoreAge Rx
#1 RecommendedFlat-rate pricing for compounded semaglutide and tirzepatide with NABP-verified pharmacies
Read Review →LifeMD
Top RatedPublicly traded telehealth company with comprehensive health platform and competitive pricing
Read Review →JumpstartMD
Comprehensive ProgramMedically supervised program with obesity medicine physicians, dietitians, and in-person options
Read Review →GoodRx Care
Trusted BrandTelehealth platform from GoodRx with transparent pricing and established trust
Read Review →Alan Meds
Top RatedAffordable compounded GLP-1s with board-certified physicians and straightforward pricing
Read Review →Boston Medical Group
Top RatedEstablished telehealth provider with physician oversight and transparent pricing
Read Review →Medical Disclaimer: This page is for informational purposes only and does not constitute medical advice. Compounded medications are not FDA-approved, are not evaluated by the FDA for safety, effectiveness or quality, and are not equivalent to the branded drug beyond sharing an active ingredient. GLP-1 medications commonly cause nausea, vomiting, diarrhoea and constipation and carry risks including pancreatitis and gallbladder disease; they are contraindicated in people with a personal or family history of medullary thyroid carcinoma or MEN 2, and should not be used in pregnancy. NAD+ products are not FDA-approved treatments and evidence for longevity claims is limited. Prescribing is subject to provider approval and is not guaranteed. Always consult a qualified healthcare provider.
Pricing Note: Pricing was checked on 29 July 2026 and is drawn from the company's published information and third-party reporting; confirm your own quote directly. This offer is not available in Alabama, Arkansas, Georgia, Hawaii, Louisiana, Mississippi, Missouri, North Dakota, South Carolina, Tennessee or West Virginia.
Affiliate Disclosure: This site may receive compensation from affiliate partners, including Enhance.MD. This does not influence our editorial content or review ratings.